Malaria is one of the oldest and most deadly infectious diseases. Together with AIDS and tuberculosis, it is listed by the World Health Organization as the top three public health problems currently facing the world. In particular, dangerous forms of malaria such as childhood cerebral malaria caused by Plasmodium falciparum kill about one million patients worldwide every year. In recent years, resistance to artemisinin-derived drugs, which are specific drugs for treating dangerous malaria, has emerged. The last line of defense for mankind against this disease is facing a major crisis of being comprehensively broken through.

Through genomic bioinformatics analysis, a "redundant" member-PfRNaseII was found in the exosome complex similar protein of Plasmodium falciparum. Through transgene and RNA sequencing technology, the control target of the PfRNase II molecule is the A-var gene: when the PfRNase II protein is functionally defective, A_The var gene is activated from "slumber", while var genes in other subtypes are not affected by this.