Supported by the National 863 Program, this project has pioneered a series of polymer microfluidic chip processing technologies based on surface in-situ polymerization and infrared-assisted embossing in the world, solving the problems of mold processing, chip rapid forming and packaging of microfluidic chips. and other technical difficulties. According to the actual needs of in vitro diagnosis and biomedical analysis, the bulk, surface and overall modification methods of polymer microfluidic chips were established, and a series of multifunctional microfluidic chips for in vitro diagnosis were designed and prepared. At the same time, a microfluidic chip instrument system for in vitro diagnosis has been developed, with multiple detection units such as ampere, conductance, microscopic imaging, ultraviolet photometry, and laser-induced fluorescence. The results of this project have good application prospects in the fields of clinical diagnosis, biomedical research, environmental monitoring and food and drug analysis. Key chip processing technologies have been authorized by 11 national invention patents.

The miniaturization and miniaturization of in vitro diagnostic instruments are important development directions and trends. Among them, microfluidic chip development is one of the development directions of clinical biochemical testing instruments. Major international diagnostic instrument companies are optimistic about this market. Microfluidic chips have the advantages of small size, controllable liquid flow, high separation efficiency, small sample consumption, fast analysis speed, and easy automated operation. They have attracted widespread attention from relevant experts in the life sciences and analytical sciences at home and abroad. They have shown good application prospects in clinical diagnosis, drug analysis, food safety, biomedical research, environmental monitoring and other fields. One of their most important application areas is disease diagnosis and screening, and it is a key to develop high-throughput clinical disease markers. Ideal platform for multi-component and low-cost testing technology. The results of this project include the design and processing technology of in vitro diagnostic microfluidic chips and the high-sensitivity and high-throughput in vitro diagnostic microfluidic chip instrument system. Our country has a large population and a large number of medical institutions. It has a great demand for products such as a series of microfluidic chips for in vitro diagnosis, high-sensitivity and high-throughput microfluidic chip instrument systems for in vitro diagnosis and supporting kits