International Cooperation and Exchange Project of the Ministry of Science and Technology "Molecular and Signaling Mechanisms that Determine Biological Characteristics such as Pluripotency of Pluripotent Stem Cells (2011DFA30480)"was completed in collaboration with Tongji University and the University of California, Los Angeles. It mainly focuses on the molecules and signaling mechanisms that determine the pluripotent biological characteristics of pluripotent stem cells, revealing the regulation of miRNAs and other induced pluripotent stem cells (iPS) formation and the regulatory role and new mechanisms of stem cell differentiation into nerves are not only of guiding significance on how to obtain high-quality iPS cells during the reprogramming process, It also provides the possibility for stem cells to differentiate into nerves to obtain therapeutic precursor cells. Published 20 high-level SCI papers in journals such as PNAS, CellRes, StemCells, etc., and trained 1 doctoral student and 4 master's students. The project leader was awarded the title of chief scientist and young scientific and technological innovation leader in major scientific research plans of the Ministry of Science and Technology, head of the innovation team of the Ministry of Education, Shanghai City's first ten "scientific research stars", special subsidies from the State Council government, introduced several outstanding young talents and related technologies, established a solid stem cell and epigenetics research team, and has been invited to Australia, Israel, Taiwan, etc. to participate in stem cell and epigenetics seminars many times to promote exchanges and cooperation.<o></o>

Many backbones of this project and many enterprises and institutions have carried out cooperative research. They have established closely connected translational medicine centers with the First Maternal and Infant Health Hospital Affiliated to Tongji University and the Tenth People's Hospital of Shanghai City to jointly study scientific problems encountered in clinical practice. At the same time, they have carried out scientific research cooperation with many hospitals such as Shanghai Changhai Hospital, Xinhua Hospital, and Changzheng Hospital affiliated to the Second Military Medical University to promote the industrialization of high-tech related to stem cells. The laboratory has currently hosted or participated in a number of major 973 projects. These projects are all related to the maintenance of differences in the totipotency of stem cells and the directed differentiation of stem cells into nerve cells to treat neurological diseases, and have promoted the solution of key scientific and technological issues in national science and technology plan projects and major projects to improve the level of project research and development.<o></o>