Application areas:

Multiscell 3D printing is currently a hot topic in international research. Through precise regulation of the spatial distribution of multiple cells in the scaffold based on 3D printing technology, it is expected to achieve a high degree of biomimetic of human tissues and be used for tissue engineering, drug screening, tissue repair, etc., and has huge market potential with broad application prospects.

Technical characteristics:

Growth factors are needed in most multicellular 3D printing processes, and the sustainability, stability and cost control of growth factors are currently difficult to solve and a pain point in the practical application of this technology. Through the design of silicon-based biomaterials, the research team achieved the continuous and stable release of active ions, thereby achieving efficient control of key biological functions such as cell survival, proliferation and differentiation during the multi-cell 3D printing process at low cost., in particular, effective enhancement of multi-cell interactions is achieved.

Performance indicators:

By accurately controlling the composition and microscopic appearance of the silicon-based biomaterial in the cell carrier material, normal survival (more than 90%) and proliferation of cells within the cell can be achieved for a long time, and cell differentiation can be significantly promoted and multi-cell interactions can be enhanced.

Current status:
At present, the project team has an independent R & D platform in Changning District, Shanghai, and has established a complete system covering material R & D-physical and chemical testing-biological evaluation. Together with cooperative clinical hospitals, it has established tissue defect models for large animals such as goats. The project team currently has pilot production capabilities.