High-frequency ultrasound (center frequency 10-100MHz) has extremely high resolution (less than 0.25-0.025mm). In recent years, it has been increasingly used for high-resolution imaging of various superficial tissues and has important clinical value. The eye is an important organ of the human body with a fine structure. When the visual path is unclear such as cataracts and fundus hemorrhage, or when opaque tissue in the eye needs to be examined, high-frequency ultrasound must be used as an imaging examination method. However, due to the particularity of high-frequency ultrasound and the development and application of high-frequency ultrasound are later than conventional ultrasound, there have always been some technical problems that need to be solved urgently, such as acoustic window artifact interference, speckled noise pollution, digitalization and informatization. The degree is low, and domestic companies lack high-frequency transducer manufacturing technology, so they can only be equipped with a single 10MHz probe, which cannot meet higher resolution requirements. We have conducted research on the above issues and made important breakthroughs.

1. According to the characteristics that the position of acoustic window artifacts in the image is determined by the distance between the transducer and the acoustic window, an original dual-transducer method is proposed to eliminate artifact interference, which effectively improves image quality.
2. For the first time in China, a 20MHz high-frequency ultrasonic transducer was developed using lithium niobate single crystal, established a complete production process, and its performance reached the international advanced level. On this basis, a 20MHz high-frequency probe was developed, which broke through the original 10MHz frequency limit and further improved the resolution power of the ophthalmic ultrasound imaging instrument.
3. For the first time in China, radio frequency (RF) echo digital processing method has been applied to high-frequency ultrasound. Through the research of this project, we have not only realized basic functions such as digital band-pass filtering, baseband transformation, down-sampling, envelope detection, and logarithmic compression for high-frequency ultrasound, but also realized adaptive filtering of radio frequency signals and advanced functions such as speckle noise suppression have significantly improved the imaging quality of high-frequency ultrasound. The establishment of this method has also laid the foundation for the development of new technologies such as high-frequency ultrasound tissue characterization, pulse compression, and Doppler signal detection.
4. For the first time, the information design of ophthalmic high-frequency ultrasound equipment was realized using an embedded control system. Due to the use of the latest high-performance embedded computers and open source operating systems, the control system is not only powerful and low-cost, but also has low power consumption, small size, and easy electromagnetic compatibility design. We integrate applications such as instrument control, image processing, database management, and image transmission in compliance with the DICOM standard in the control system.
5. A variety of innovative high-frequency ultrasound probes for ophthalmic applications have been designed, laying the foundation for further improving imaging quality and expanding the application scope of ophthalmic ultrasound.

On the basis of the above research results, we have developed the RU-1020CG digital ophthalmic high-frequency ultrasound imaging instrument using the combination of industry, academia and research model, which has realized the commercialization and clinical application of technology and promoted the progress of high-frequency ultrasound imaging technology in my country., improving the technical level of ophthalmic ultrasound diagnostic equipment and providing effective means for clinical units to improve the level of diagnosis and treatment. This project passed third-party technical inspection and obtained the three-category medical device registration certificate from the State Food and Drug Administration. So far, this equipment has been used by more than 100 hospitals in China, benefiting more than 800,000 patients, and a cumulative output value of more than 4 million yuan. This project has obtained 1 invention patent, 4 utility model patents, published 14 papers, and trained 12 graduate students.