1. application field

This equipment platform can be used for particle size control research on drug carriers including liposomes, polymer micelles, drug-loaded microspheres and metal-organic framework particles. It solves the problems of poor batch stability of particulate products, cumbersome and inefficient labor to control parameters in the research and development process of micro and nano scale self-assemblies.

2. technical characteristics

The platform effectively combines advanced technologies such as microfluidic self-assembly synthesis, high-throughput experimental screening and automated control. It can automatically adjust multiple technical parameters such as microfluidic synthesis driving method, flow rate, reaction raw material concentration, solvent type and ratio. Self-assembled particle solution samples obtained from different parameter combinations are continuously and automatically subjected to steps such as collection, purification, dilution and online particle size detection. Finally, the best technical parameter combination is quickly screened out based on machine learning. and is directly applied to macro synthesis.

3. performance Index

Single batch of 48 samples, continuous synthesis, collection, inspection, data storage and analysis of 50 batches (completed in about 12 hours) of nanopharmaceutical samples; compatible with multiple microfluidic synthetic chip structures; the syringe pump flow rate is 1 ml/The range of min-100ml/min is adjustable; the best synthesis scheme is selected within 24 hours.

4. current state

Complete prototype development.