This project belongs to the field of pathophysiology. Promoting angiogenesis is an important strategy for the treatment of cardiovascular diseases. Pathological vascular remodeling is the pathological basis of many cardiovascular diseases. Therefore, in-depth research on the regulatory mechanisms of angiogenesis and vascular remodeling is of great significance for exploring new therapeutic targets for cardiovascular diseases. The project has carried out a series of research focusing on the key scientific issues of ldquo; regulation mechanisms of angiogenesis and vascular remodeling and prevention and treatment of cardiovascular diseases. The contents are as follows: (1) It reveals new mechanisms of angiogenesis regulation and clarifies that Bach1 is a new target for promoting angiogenesis and treating cardiovascular diseases. A new key transcription factor Bach1 with ldquo; master switch rdquo; effect was discovered to regulate angiogenesis, clarifying for the first time a new role and new mechanism of inhibiting Bach1 expression and promoting angiogenesis in ischemic cardiovascular diseases. It was the first to propose a new role of miRNA-320 in regulating myocardial angiogenesis. Representative papers were published in Circulation Research et al., and he cited 186 times in SCI. The Lancet sub-issue has repeatedly cited this work and commented that the project reveals that Bach1 is a new target for intervention in cardiovascular disease. The European Heart Journal published a special review, which introduced this work in half a page and summarized it into a map and elaborated it in detail. Evaluating this work is extremely important for the research of myocardial angiogenesis. Candidates were invited by the editor-in-chief of Oxid Med Cell Longev to write a special review of progress in the field. (2) It reveals a new mechanism by which reactive oxygen species regulate pathological vascular remodeling and provides a new target for the prevention and treatment of cardiovascular diseases. It clarifies a new mechanism by which reactive oxygen species promote the proliferation and migration of vascular smooth muscle cells, promote atherosclerosis and pathological vascular remodeling. Representative papers were published in Cardiovascular Research et al., and he cited 99 times in SCI. Ashok K., a famous scholar in the field of cell biology. Professor Srivastava quoted this work five times in a special review published in Antioxidants amp; Redox Signaling and specifically summarized it into a graph, pointing out that this work clarified the extremely important role of reactive oxygen species in vascular biology. A review published by Circulation pointed out that the work reveals that reactive oxygen species are drug targets for the treatment of cardiovascular diseases. (3) Clarifies a new theory that reactive oxygen species regulate the differentiation of stem cells into vascular endothelial cells, providing a new strategy for stem cells to treat ischemic cardiovascular diseases. It was found that reactive oxygen species derived from Nox2 promote the differentiation of stem cells into arterial endothelial cells and regulate angiogenesis after ischemia in mice. Representative papers were published in Scientific Reports, etc., and he cited 46 times in SCI. Mark T., University of Pittsburgh Professor Gladwin evaluated this work many times in Physiological Reviews, revealing the key role of reactive oxygen species in angiogenesis. Professor Iruela-Arispe of the United States published a review stating that the project clarified that stem cells play an important role in angiogenesis treatment. This project has published 13 SCI papers (including 1 IF gt;15 paper and 3 IF gt;5 papers) in internationally renowned journals such as Circulation Research and Cardiovascular Research, and has been widely cited in world-class journals. SCI cited 394 times, and a single article cited 159 times. It was rated as a highly cited paper in this journal. Hosted 5 projects under the National Natural Science Foundation of China, delivered more than 20 thematic reports at international and domestic academic conferences, and authorized and applied for 3 China patents.