This project belongs to the field of new materials and is an intersection of metal surface modification and medical engineering materials. Bacterial infection and slow osteogenesis are the two primary causes of clinical failure of bone implant medical devices. Aiming at the scientific issues that traditional silver nanoparticles are highly toxic, uncontrollable antibacterial activity, and incompatible antibacterial and osteogenesis, the project explores the principle and technology of embedding nano-antibacterial metal particles, and proposes that based on ldquo; microbattery corrosion rdquo; and ldquo; Schottky contact rdquo; effects give medical titanium alloys ldquo; safe antibacterial rdquo;, ldquo; rapid osseointegrationrdquo; and ldquo; antibacterial and osteogenic rdquo;, and conducts systematic medical transformation research, laying a scientific and technical foundation for the development of ldquo; antibacterial rdquo; or ldquo; osteogenic and antibacterial rdquo; bone implant devices and their clinical applications. The key scientific discoveries include the following three points:(1) Develop ldquo; atomic-scale heating; build ldquo; inlaid metal nanoparticle technology, and propose ldquo; microbattery corrosion; and ldquo; Schottky contactrdquo; antibacterial models to provide a safe and effective solution for the development of antibacterial bone implant devices. (2)It was found that building a nano-modified layer that stores active elementsrdquo; on the surface of titanium alloy can promote osteogenesis on the surface of titanium alloy and improve the biological utilization of active components, providing new ideas for realizing rapid osseointegration of implants. (3)Invented the ldquo; binary ion co-implantation technology and proposed the ldquo; dual-functional microbattery corrosion/antibacterial model, providing a new solution for the development of osteogenic and antibacterial bone implant devices. The project is funded by the National Fund for Distinguished Young Scholars, ldquo; 12th Five-Year Plan;973 Project, multiple National Natural Science Foundation of China, and Shanghai City Basic Key Projects. So far, 62 papers have been published in authoritative journals in Biomaterials, Acta Biomateralia, Materials Science and Engineering R (including 17 IF gt;5), and have been evaluated and cited by authoritative journals in Biomaterials, Chemical Reviews, Angewandte Chemie International Edition and other fields, with SCI citing 1645 times. He cited 8 representative papers in SCI 743 times, with a single paper up to 159 times, with an average of 92 times. Authorized 12 China invention patents. Cultivate 11 doctoral students and 8 master's students, 2 of whom received national scholarships for postgraduate students. Project completion person Liu Xuanyong was funded by the National Outstanding Young Persons Fund (2015) and was selected into the National ldquo; Ten Thousand Talents Program (2018), Young and Middle-aged Scientific and Technological Innovation Leading Talents of the Ministry of Science and Technology (2016), Shanghai City Natural Science Peony Award (2015), and Shanghai City Outstanding Academic Leaders and other talent programs (2014). Cao Huiliang was selected into ldquo; Youth Innovation Promotion Association of China Academy of Sciences (2015) rdquo; and Shanghai City ldquo; Youth Science and Technology Star Program (2015) rdquo;. Zhang Xianlong was selected as Chairman of the Editorial Committee of the Asia-Pacific Consensus on Artificial Joint Infection (2018) rdquo; and Chairman of the China Professional Committee on Artificial Joint Infection (PJI)(2018) rdquo;. Based on the surface modification principles discovered in the project, a new titanium internal fixation system was developed. Through the company, 1 registration certificate for implanted medical devices has been obtained. Since 2014, more than 140,000 cases have been used clinically. Project development The biosafety of nano-silver antibacterial technology has been certified by an authoritative body recognized by the State Food and Drug Administration (CFDA), and the ldquo; Shanghai Institute of Silicate, China Academy of Sciences Cixi Biomaterials Surface Engineering Center rdquo; Industrial incubation was established. During the implementation of the project, a new multi-functional surface modification system was developed (installed in October 2016) to lay a supporting foundation for equipment for the industrialization of related surface modification technologies. In short, this project has promoted the development of the science and technology of surface functionalization of bone implant medical devices, and has important academic value and broad application prospects.